|
Cat. No. |
CAB331 |
|
Antigen
Information |
CD45 leukocyte
common antigen (LCA) belongs to the family of at least four
isoforms of membrane glycoproteins (220, 205, 190, 180kDa)
expressed on hematopoietic cell lines but absent on non-hematopoietic
cell lines, normal and malignant non-hematopoietic tissues. The
intracellular portion of these molecules has protein phosphatase
activity and is involved in regulation of transmembrane signals. |
|
Immunogen |
Purified human
T-Cells. |
|
Ig Subclass |
Mouse IgG2a. |
|
Purification
Method |
Protein-A. |
|
Protein
Concentration |
1mg/ml in PBS
(after reconstitution). |
|
Available
Conjugates |
This antibody
is only available conjugated to Biotin and FITC.
For staining
with biotin or FITC-conjugated antibody use 5-10µl/106 cells. |
|
Antibody
Properties |
Staining
antibody. For staining, use 10µl/106 cells. |
|
Stability /
Shelf Life |
Two years
lyophilized, one month in solution at 4°C. |
|
Reconstitution |
Reconstitute
with of H2O. Mix gently, wash the sides of the vial
and wait 30-60 seconds before use. |
|
Storage |
Lyophilized:
store at 4°C. After reconstitution, if not intended for use
within a month, aliquot and store at -20°C. |
|
Gene
Information
|
Gene Name |
PTPRC protein tyrosine phosphatase, receptor type, C [ Homo
sapiens ] |
|
Synonyms
|
PTPRC; protein
tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45;
T200; CD45R; GP180; CD45 antigen; glycoprotein; T200
glycoprotein; leukocyte-common antigen; T200 leukocyte common
antigen; protein tyrosine phosphatase, receptor type, c
polypeptide; Leukocyte common antigen; L-CA; EC 3.1.3.48;
protein tyrosine phosphatase, receptor type, c polypeptide |
|
GeneID |
5788 |
|
mRNA Refseq |
NM_002838 |
|
Protein Refseq |
NP_002829 |
|
MIM |
151460 |
|
UniProt ID |
P08575 |
|
Chromosome
Location |
1q31-q32 |
|
Pathway |
Cell adhesion
molecules (CAMs); Fc gamma R-mediated phagocytosis; Primary
immunodeficiency; T cell receptor signaling pathway; Axon
guidance; :Signaling in Immune system |
|
Function |
heparan sulfate
proteoglycan binding; heparin binding; hydrolase activit;
protein binding; protein kinase binding; transmembrane receptor
protein tyrosine phosphatase activity |
|
|
Abbr.: 
