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Cat. No.
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CAB031
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Antigen information
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The enzyme encoded by UGP2 gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. So far two transcript variants encoding different isoforms have been found for this gene.
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Immunogen
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Cytosolic proteins of human adult liver tissues (fraction 1)
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Specificity
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Recognizes recombinant UGP2 (Homo sapiens UDP-glucose pyrophosphorylase 2) at the molecular weight of 53kD and native protein at 56kDa.
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Isotope
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Mouse Monoclonal IgG2bκ
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Clone
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BAD062
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Species Cross-reactivity
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Human. Others not determined.
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Formulation
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200μg of protein G purified IgG2b(κ) in 172μL of 70% storage buffer (0.1M Tris-HCl, pH 7.4, 0.15M NaCl, 0.04% merthiolate) and 30% glycerol.
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Handling Recommendations
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Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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Applications
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This antibody is effective in ELISA, and immunoblotting for both tagged and native proteins.
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Recommended Working Dilution
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The optimal working dilution should be determined according to each specific assay condition.
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Gene Information
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Gene Name
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UGP2
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Synonyms
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UDPG; UGPP2; UDPGP2; pHC379; UGP2; UDP-glucose pyrophosphorylase 2;UGPase 2; UDP-glucose diphosphorylase; UTP-glucose-1-phosphate uridyltransferase; UTP--glucose-1-phosphate uridylyltransferase 2; uridyl diphosphate glucose pyrophosphorylase 2
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GeneID
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7360
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mRNA Refseq
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NM_001001521
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Protein Refseq
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NP_001001521
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MIM
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191760
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UniProt ID
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Q16851
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Chromosome Location
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2p14-p13
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Pathway
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Galactose metabolism; Nucleotide sugars metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Biological oxidations; Metabolism of carbohydrates.
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Function
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UTP:glucose-1-phosphate uridylyltransferase activity; nucleotidyltransferase activity; protein binding; transferase activity
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