Mouse CLCN5 Monoclonal Antibody   [ Back  ]                         Price Inquiry

Cat. No.

CAB008

Antigen information

CLCN5 is a voltage-gated chloride channel protein. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. CLCN5 may play an important role in renal tubular function. CLCN5 is a multi-pass membrane protein and moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle in kidney. It is related with many diseases such as kidney stone, Dent Disease, Nephrolithiasis and so on.  

Isotope

Mouse Monoclonal IgG1κ

Immunogen

Recombinant human GST-CLCN5 protein.

Applications

This antibody is effective in ELISA, Western blot, IH and IF.

Specificity

Recognizes CLCN5 in total lysates of human HSG cells with MW of 83 kDa and GST-CLCN5 with MW of 32 kDa.

Species Cross-reactivity

Human. Others not determined

Formulation

200 μg of protein G purified IgG1κ in 172μL of 70% storage buffer (0.1M Tris-HCl, pH 7.4, 0.15M NaCl, 0.04% merthiolate) and 30% glycerol.

Handling Recommendations

Aliquot into microcentrifuge tubes and stored at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. 

Recommended Working Dilution

The optimal working dilution should be determined according to each specific assay condition.

Gene Information

Gene Name

CLCN5

Synonyms

CLC5; CLCK2; DENTS; NPHL2; XLRH; XRN; hCIC-K2; hClC-K2; chloride channel 5; chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease); OTTHUMP00000023279; OTTHUMP00000023280; OTTHUMP00000023281; OTTHUMP00000023282; NPHL1; ClC-5; nephrolithiasis 2, X-linked

GeneID

1184

mRNA Refseq

NM_000084

Protein Refseq

NP_000075

MIM

300008

UniProt ID

P51795

Chromosome Location

Xp11.23

Function

chloride ion binding;voltage-gated chloride channel activity; voltage-gated ion channel activity