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Cat. No.
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CAB001
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Antigen information
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular(apical) part of the hepatocyte and functions in biliary transport.Substrates include anticancer drugs such as vinblastine; therefore,this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
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Immunogen
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Mixed immunization with His-tagged ABCC2 (1366-1545aa), His-tagged PRDX2 (1-192aa), His-tagged PRDX3 (80-257aa) and His-tagged PRDX4 (98-271aa).
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Specificity
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Recognizes recombinant ABCC2 (homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 2) at predicted 37 kDa.
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Species Cross-reactivity
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Human. Others not determined.
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Formulation
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200μg purified monoclonal antibody by protein G in storage buffer (0.1M Tris-HCl, pH 7.4, 0.15M NaCl, 0.04% merthiolate) and 50% glycerol.
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Handling Recommendations
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Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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Applications
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This antibody is effective in ELISA, immunoblotting, and immunofluorescence.
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Recommended Working Dilution
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The optimal working dilution should be determined according to each specific assay condition.
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Gene Information
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Gene Name
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ABCC2
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Synonyms
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ABC30; CMOAT; DJS; KIAA1010; MRP2; cMRP; OTTHUMP00000020267;canalicular multispecific organic anion transporter; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; Canalicular multidrug resistance protein; CMOAT1; ATP-binding cassette sub-family C member 2.
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GeneID
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1244
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mRNA Refseq
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NM_000392
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Protein Refseq
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NP_000383
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MIM
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601107
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UniProt ID
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Q92887
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Chromosome Location
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10q24
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Pathway
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ABC transporters - General
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Function
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ATP binding; ATPase activity; coupled to transmembrane movement of substances;nucleotide binding; organic anion transmembrane transporter activity; protein binding; transporter activity.
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Download Datasheet:
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